Objective To analyze the application value of ultrasound combined with CT in the identifying the nature of breast lumps. Methods The ultrasound and CT imaging data of 68 patients with breast lumps who were admitted into our hospital between June 2011 and May 2015 were retrospectively analyzed. The accuracy rates of CT, ultrasound and the combination in the diagnosis of breast lumps were compared. The value of them in the differential diagnosis of benign and malignant breast lumps was analyzed. Results 18 cases (78.26%) of benign lumps and 39 cases (86.67%) of malignant ones were detected by ultrasound and the overall coincidence rate was 83.82%, 20 cases (86.96%) of benign lumps and 39 cases (93.33%) of malignant ones were detected by CT and the overall incidence rate was 91.18%, 22 cases (95.65%) of benign lumps and 43 cases (95.56%) of malignant ones were detected by the combined diagnosis and the overall coincidence rate was 95.59%, There was a high degree of coincidence between the combined diagnosis and pathology. Compared with ultrasound single diagnosis, the difference was statistically significant (P<0.05). Conclusion Ultrasound combined with CT in diagnosis of breast lesions is of high coincidence with pathology. The value of differential diagnosis of benign and malignant lumps is high. For nonpalpable lesions, ultrasound in diagnosis of suspected malignant lesions should be combined with CT for auxiliary screening, which can improve the detection rate.