Objective To evaluate the value of endoscopic ultrasonography and abdominal CT in the differential diagnosis of pancreatitis in different stages. Methods Seventy-two patients with chronic pancreatitis treated in our hospital between June 2012 and June 2016 were selected as study subjects. All underwent endoscopic ultrasonography and abdominal CT, and the imaging findings were analyzed and compared with the results of clinical staging. The diagnostic positive rate of clinical stage were compared between the two methods. Results The positive rate of endoscopic ultrasonography in the diagnosis of pancreatitis in stage 1 was 81.48%, significantly higher than that of abdominal CT (55.56%) (P＜0.05). There were no significant differences in the diagnostic positive rate of stage 2 and stage 3 between the two methods (P＞0.05). Imaging findings of endoscopic ultrasonography: the enhanced images of pancreatic tissues in stage 1 and 2 were the same with surrounding tissues, blood vessels in glandular tissues showed homogeneous enhancement; blood vessels in glandular tissues in stage 3 showed sparse, inhomogeneous and low enhancement; Imaging findings of abdominal: the boundaries of pancreas in stage 1 was relatively clear, the density was relatively homogeneous; in stage 2, the boundaries were relatively blur and the density was inhomogeneous, there were different degrees of enlargement of pancreas and strip or patchy high density shadow; in stage 3, the fat layer surrounding pancreas disappeared, the outline was fuzzy, and there were low-density necrosis and different degrees of hydrops and high-density hematocele surrounding pancreas. In stage 1-3, there were different degrees of enhancement. Conclusion Both of endoscopic ultrasonography and abdominal CT is with high positive diagnostic rate and different imaging findings in the diagnosis of pancreatitis in different stages. The two methods can be chosen according to the actual situation.