Objective To evaluate the significance of spiral CT, indirect lymphography and multi phase enhanced scan on sentinel lymph node in gastric cancer. Methods The data were collected from the department of image in the Fifth People's Hospital of Zhuhai city during 2012 June to 2014June. SLN samples were obtained from the T0 of gastric cancer (50 cases), cT1-2patients (35 male and 29 female). All checks were performed in the Fifth People's Hospital of Zhuhai city, such as SLN imaging, biopsy and subsequent laparotomy laparoscopic gastrectomy, gastric partial hysterectomy and gastricresection. And all the patients were underwent spiral CT indirect lymphography and multi phase enhancement scanning. Results During the T0, Tis, T1, T2, T3 period, the detected number between indirect lymphography, multi phase enhanced scanning, indirect lymphography + multiphase enhanced scanning and biopsies had no difference. But during the T4 period, indirect lymphography detected 51 cases (62.96%), multi phase scan detected 61 cases (75.30%), indirect lymphography + multi phase scan detected 81 cases (100%), and there was significant difference between the four methods (X2 =9.271, P=0.000). The detected number of N1, N2 in the four methods were statistically significant difference (P <0.05) , the X2 value were 6.262, 3.199 respectively. The detection rate of helical CT three phases enhanced images was higher than that used indirect CT lymphography (X2 =8.482, P=0.000). Conclusion Spiral CT indirect lymphography and multi phase enhanced scan of sentinel lymph node in gastric cancer can help us make judgment and provide preoperative and intraoperative basis for sentinel gastric cancer sentinel lymph node cleaning，and lay the foundation for the clinical application of minimally invasive operation of gastric cancer. Meanwhile the accurate staging of gastric cancer and lymph node involvement judgment also provides image reference for operation, so as to achieve the reasonable operation of gastric cancer clinical treatment.