Objective To explore CT findings of giant uterine leiomyoma and to improve its diagnostic accuracy. Methods 26 patients of pathologically-proved giant uterine leiomyoma who had typical CT signs were selected (all cases had CT MRP reconstruction; 12 cases with enhanced scan). Results The maximal diameter of giant uterine leiomyoma ranged from 9-35 cm. The lesions located at subserous of uterus (n=8), the broad ligament (n=5), the myometrium (n=11), the uterus cervix (n=2). 7 cases demonstrated homogeneous density similar to normal uterus tissue on CT scans. 17 cases demonstrated heterogeneous density and the other 2 cases demonstrated cysticsolid mixed. 11 cases demonstrated obviously inhomogeneous enhancement with multiple small vessels observed; only 1 case demonstrated mild inhomogeneous enhancement. 6 cases were complicated by ovarian tumors or cysts, and 1 case was misdiagnosised. 7 cases demonstrated atypical CT findings. Pathology proved hyaline degeneration in 11 cases; 6 cases mucoid degeneration; 2 cases cystic degeneration. Conclusion Giant uterine leiomyoma have some characteristics in CT findings; grasps its images features is helpful for the diagnosis. However, atypical manifestation of giant uterine leiomyoma should be reminded to the differential diagnosis.