Objective This paper is to discuss the value of CT in diagnosis of autoimmune hepatitis and nursing intervention measures and to provide the reference for clinical practices in the future. Methods Forty patients with autoimmune hepatitis admitted by this hospital during the period from January, 2009 to January, 2014 were selected as research subjects, who were retrospectively analyzed and studied according to the clinical data, and CT manifestation o and nursing intervention of autoimmune hepatitis were explored. Results Twelve patients are found to have liver volume increased, 8 patients suffered from liver atrophy, 19 patients were confirmed to have nodular change in liver parenchyma, 11 patients were found to have uneven liver parenchyma strengthening. 23 out of 40 patients suffered from lymphadenectasis, 12 patients had retroperitoneal lymph node enlargement, 9 patients were found to suffer from synchronous enlargement of peritoneal cavity and retroperitoneal lymph node. Clinical symptoms of patients significantly improved after nursing when compared to that of patients before nursing (p<0.05), the differences were statistically significant. Conclusions CT delivers important clinical value in the diagnosis of autoimmune hepatitis, corresponding image assumes certain characteristics, and it provide important diagnostic basis for clinical treatment. Effective nursing intervention can significantly improve clinical symptoms of patients and improve treatment effects, being worthy of wide application and promotion in clinical practices.