Objective To explore the clinical features, imaging appearance and differential diagnosis of chromophobe cell renal carcinoma (CCRC). Materials and Methods The clinical datas, CT and MRI manifestations of 16 patients with CCRC confirmed by pathology were reviewed retrospectively. Results 16 cases of CCRC were solitary lesion, 9 cases located in right kidney and 7 in left kidney. The tumors ranged in size from 4 to 14 cm in diameter, with round or shallow lobulation in 14 cases and "8" shape in 2 cases. The density of 9 cases were homogeneous on CT plain scan, iso-/slightly hypo-intensity on T1WI and iso-/slightly hyper-intensity on T2WI; Two cases were inhomogeneous, iso-/hypo-mixed signal on T1WI and hyper-/hypo-mixed signal on T2WI, punctate, small strip calcification in 2 cases, stellate scar in 2 cases and all no hemorrhage. 14 cases with clear boundary, of which 13 showed slight to moderate enhancement and 1 obvious enhancement, parenchymal phase was higher than corticomedullary phase, lower than the renal cortex; 2 cases wih blurry boundary, of which one has obviously cystic necrosis, showed obvious heterogeneous enhancement, the other together with inflammation around the renal, the excretory phase higher than corticomedullary phase and the parenchymal phase. Conclusion The clinical manifestation of CCRC without specificity, imaging performance has certain specificity, but it's easily misdiagnosed when the tumor accompanied by larger volume, more necrosis and cystic fasciitis, with inflammation around the renal.