Objective To compare and analyze the correlation between CT liver volume measurement and liver function grading in patients with hepatitis B complicated with liver cirrhosis. Methods 82 cases of patients with hepatitis B complicated with liver cirrhosis admitted to our hospital from March 2015 to March 2018 were selected as case group. According to the Child-Pugh classification criteria, they were divided into 25 cases in grade A group, 34 cases in grade B group and 23 cases in grade C group, and all patients were given CT examination at 1 w before liver biopsy. Another 41 patients with same age group who were given upper abdominal CT enhanced scan due to other reasons at the same time period were selected as control group. Case group and control group were given CT liver volume measurement. The liver lobes volumes (lobus sinister lateralis, lobus sinister medialis, right anterior lobe, right posterior lobe, caudate lobe) and total liver volume were observed among the four groups, and the liver volume and Child-Pugh classification were given correlation analysis. Results There were significant differences in the lobus sinister lateralis, lobus sinister medialis, right anterior lobe, right posterior lobe and caudate lobe volumes and total liver volume between case group and control group (P<0.05). There were no statistically significant differences in the percentages of lobus sinister lateralis, lobus sinister medialis, right posterior lobe and caudate lobe volume in total liver volume among groups in case group (P>0.05). And there was a statistically significant difference in the percentage of right anterior lobe volume in total liver volume among groups in case group (P<0.05). According to Pearson correlation analysis, the total liver volume in case group was negatively correlated with Child-Pugh classification (r=- 0.206, P<0.05). Conclusion CT liver volume of patients with hepatitis B complicated with liver cirrhosis is smaller than that of normal people, and it is shrinking with the severity of liver cirrhosis.