目的 研究观察热性惊厥患儿血清脑利钠肽(BNP)与钠离子(Na+ )水平情况，并分析其临床作用及意义。方法 选取 2014年4月-2015年10月收治的热性惊厥患儿52例作为研究对象(FC组)，另选取同期上呼吸道感染发热但无惊厥患 儿50例作为发热对照组(URI组)，健康体检儿童50例作为健康对照组(对照组)，对比观察各组血清BNP及Na+ 水平 情况。结果 FC组血清BNP水平明显高于URI组及对照组，Na+ 水平明显低于URI组及对照组，差异有统计学意义(P ＜0.05)，URI组与对照组两指标水平差异不明显，不具有统计学意义(P＞0.05)；血清BNP与Na+ 水平之间存在负相 关关系(P＜0.01)。结论 热性惊厥患儿血清BNP水平明显升高、Na+ 水平明显降低，这可能与BNP分泌对醛固酮系统 形成抑制，从而引起血钠降低有关，会进一步促使惊厥发作，因此患儿血清BNP、Na+ 水平对其病情、治疗及判断预 后均有重要的临床意义。

Objective To investigate serum brain natriuretic peptide (BNP) and sodium ions (Na+ ) levels in patients with febrile convulsions, and analyze their clinical role and significance. Methods 52 cases of febrile convulsions from April 2014 to October 2015 were selected for the study (FC group), another upper respiratory tract infection fever earlier but no seizures in children with fever 50 cases were selected as the control group (URI group), 50 cases of healthy children as healthy control group (control group), the serum levels of BNP and Na+ situation were compared. Results FC serum BNP levels were significantly higher than URI group and control group, Na + levels were significantly lower than the URI group and control group, the difference was statistically significant (P<0.05), two indicators of the level difference URI group and control group was not obvious, not statistically significant (P>0.05). There was a negative correlation (P<0.01) between serum BNP and Na+ levels. Conclusion Febrile convulsions serum BNP levels were increased, Na+ levels were lower with statistical significance, which may be related to BNP secretion of aldosterone inhibitory system and decreased serum sodium, will further promote the seizures. In a word, the serum BNP, Na+ the level have important clinical significance for their condition, treatment and prognosis.