目的 探讨胶原酶治疗椎间盘膨出的临床价值。方法 对61例椎间盘膨出症患者在CT定位下经皮侧方进针直接进入椎 间盘内部，并注入胶原酶。结果 61例穿刺65针，穿刺成功率100%，全部患者短期(3-6个月)内腰部疼痛及肢体麻木 症状明显减轻,28例于术后3-6个月复查CT，均可见椎间盘内出现空腔，70%椎间盘膨出度无明显改变，20%椎间盘膨 出度轻微回缩,10%神经根压迫症状有改善。结论 CT定位下穿刺治疗椎间盘膨出，操作方便，安全性高，创伤小。

Objective To investigate the clinical value of collagenase in the treatment of lumbar disk bulging. Methods 61 cases of lumbar disc bulging patients accepted CT-guided percutaneous injection of collagenase chemonucleolysis. Results A total of 65 needles were punctured, puncture success rate of 100%. The lumbar pain and numbness of limb were relieved after surgery in short-term (3-6 months), and intervertebral disc cavity could be seen in 28 cases of CT review after surgery. 70% patients had no significant change in the degree of disc bulge, 20% of the mild disc bulge retraction, 10% of the nerve root compression symptoms have improved. Conclusion It’s convenient, safe, and less trauma by CTguided percutaneous injection of collagenase chemonucleolysis in the treatment of lumbar disc bulging.