目的 探究术前核磁共振成像 (MRI)在评估不同质地垂体瘤中的应用价 值。方法 收集2012年1月-2017年6月于 我院行手术治疗的98例垂体瘤患者的临 床病例、MRI影像学检查资料进行回顾性 分析，术前均行头颅MRI扫描，并根据 术中所见垂体瘤质地将其分为质地软组 (n=66)和质地韧组(n=32)，使用天狼猩 染色检测肿瘤胶原含量。结果 两组性 别、肿瘤大小、功能类型及其生长方式的 差异均无统计学意义(P>0.05)；两组在 T1WI瘤体与白质信号强度间比较差异无 统计学意义(P>0.05)，质地软组T2WI瘤 体与白质信号强度比(2.13±0.58)%显著 强于质地韧组(1.38±0.42)%，差异有统 计学意义(t=6.525，P<0.05)；质地软组 胶原含量(8.72±2.48)%显著低于质地韧 组(28.39±12.72)%，差异有统计学意义 (t=12.158，P<0.05)；T2WI瘤体与白质 信号强度与胶原含量具明显负相关性(r=- 0.785，P<0.05)。结论 胶原沉积是垂体 瘤质地变坚韧的显著病理特征，可将T2WI 瘤体与白质信号强度比作为术前评估垂体 瘤质地的主要参考指标，指导手术入路的 选择。

Objective To explore the application value of preoperative magnetic resonance imaging (MRI) in the evaluation of different textures of pituitary tumors. Methods The clinical cases and MRI findings of 98 patients with pituitary tumors who underwent surgical treatment in our hospital from January 2012 to June 2017 were retrospectively analyzed. All patients were given cranial MRI scans before surgery, and they were divided into soft group (n=66) and firm group (n=32) according to the textures of pituitary tumors seen during operation. The collagen content in the tumor was detected by Sirius-Red staining. Results There was no significant difference in gender, tumor size, function type and growth patterns between the two groups (P>0.05). There was no significant difference in signal intensity ratio of T1WI tumor and white matter (P>0.05), and the signal intensity ratio of T2WI tumor and white matter in soft group was significantly higher than that in firm group [ (2.13±0.58)% vs (1.38±0.42)%] (t=6.525, P<0.05). The collagen content in soft group was significantly lower than that in firm group [(8.72±2.48)% vs (28.39±12.72)%] (t=12.158, P<0.05). The signal intensity ratio of T2WI tumor and white matter was negatively correlated with collagen content. (r=-0.785, P<0.05). Conclusion Collagen deposition is a significant pathological feature of pituitary tumor toughening. The signal intensity ratio of T2WI tumor and white matter can be used as the main reference index for preoperative evaluation of textures of pituitary tumors so as to guide the choice of surgical approach.