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18F-FDG PET/CT显像 联合血清CA19-9对 宫颈癌复发及转移 的诊断价值分析

作者:张双凤1 薛秀珍2 杨会莉3

所属单位:1.义煤集团宜阳义络煤业有限责任 公司医院妇产科 (河南 洛阳 471600) 2.河南科技大学第一附属医院妇产 科 (河南 洛阳 471003) 3.河南省洛阳市宜阳县中医院放射 科 (河南 洛阳 471600)

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摘要

目的 探讨18F-氟代脱氧葡萄糖 (18F-FDG)正电子发射断层显像术/计算机 体层扫描(PET/CT)显像联合血清糖类抗原 19-9(CA19-9)对宫颈癌复发及转移的诊断 价值。方法 回顾性分析2015年1月-2018 年1月我院收治的62例宫颈癌根治术后疑 似复发和转移患者的临床资料。所有患 者均行18F-FDG PET/CT检查,以组织病理 学或随访结果为“金标准”,评价PET/ CT检查、血清CA19-9检测以及两者联合检 查对宫颈癌复发及转移的诊断价值,并比 较差异性。结果 18F-FDG PET/CT、联合 检查诊断对宫颈癌复发及转移的灵敏度、 特异度、准确率均高于血清CA19-9检测 (P﹤0.05),且与组织病理学或随访结果 的吻合度高(kappa值=0.763、0.950,P﹤ 0.05)。结论 18F-FDGPET/CT显像可清晰准 确显示宫颈癌患者术后复发及转移情况, 联合血清CA19-9联合诊断价值较高,有助 于全面评估患者病情。

Objective To explore the diagnostic value of 18F-fluorodeoxyglucose (18FFDG) positron emission tomography/computed tomography (PET/CT) imaging combined with serum carbohydrate antigen 19-9 (CA19-9) on the recurrence and metastasis of cervical cancer. Methods The clinical data of 62 patients with suspected recurrence and metastasis after radical resection of cervical cancer from January 2015 to January 2018 were analyzed retrospectively. All patients were given 18F-FDG PET/CT examination. Histopathology or follow-up results were regarded as gold standards to evaluate the diagnostic value of PET/CT, serum CA19-9 and combined examination for recurrence and metastasis of cervical cancer and compare the differences. Results The sensitivity, specificity and accuracy of 18F-FDG PET/CT and combined examination for recurrence and metastasis of cervical cancer were higher than those of serum CA19-9 (P<0.05), and they were highly consistent with histopathology or follow-up results (kappa value=0.763, 0.950, P<0.05). Conclusion 18F-FDG PET/CT imaging can clearly and accurately show the recurrence and metastasis of patients with cervical cancer. Serum CA19-9 has high diagnostic value, and can comprehensively evaluate the patients' conditions.

【关键词】18F-FDG PET/CT;CA19-9;宫 颈癌;复发;转移

【中图分类号】R737.33

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.04.032

前言

宫颈癌是妇科常见恶性肿瘤疾病,经根治术治疗后可取得一定疗 效,但术后可能发生复发或转移,严重影响患者生存期和生活质量, 因此在根治治疗后应定期进行复查,了解预后情况。血清肿瘤标记物 是操作简单、价格低廉的一项检测方式,可作为恶性肿瘤的筛选指 标,但特异度不高,需结合其他检查进一步确诊[1]。超声、CT、MRI等 检查是常见的影像学复查方式,可对部分复发、转移病灶进行清晰的 显像,但对于全身转移灶的显像较为局限且准确性欠佳,而临床上需 及早诊断宫颈癌复发、转移,以利于后续治疗方案的选择[2]。18F-氟代 脱氧葡萄糖正电子发射断层显像术/计算机体层扫描(18F-FDGPET/CT, 下文简称PET/CT)是一种新型影像学技术,可同时显示组织结构形态和 功能状态,尤其对于全身肿瘤病灶的探测和定位有较高的应用价值, 现广泛应用于恶性肿瘤的诊断和疗效评价[3]。本研究旨在探讨PET/CT联 合血清糖类抗原19-9(CA19-9)对宫颈癌复发及转移的诊断价值,现报 道如下。