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螺旋CT灌注成像与 超声超微细血流成 像在评估肝癌介入 术后活性病灶血供 中的应用比较

作者:刘 洋1 寻 航1 李修奎1 姚鹏飞2

所属单位:1.山东省临沂市肿瘤医院影像科 (山东 临沂 276001) 2.山东省临沂市临沭县人民医院影 像科 (山东 临沂 276700)

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摘要

目的 比较螺旋CT灌注成像(CT perfusion imaging,CTPI)与超声超 微细血流成像(superb microvascular imaging,SMI)在评估肝癌介入术后活性 病灶血供中的应用价值。方法 选取我院 收治的48例行肝癌介入术治疗患者,均于 术后6周接受螺旋CT灌注成像与超声超微 细血流成像检查,以数字减影血管造影 (Digital Subtraction Angiography, DSA)为“金标准”,比较CTPI与SMI评估 肝癌介入术后活性病灶血供准确性。结 果 DSA检查显示,52枚病灶中,有血供 46枚,无血供6枚;CTPI检查术后活性病 灶血供灵敏度95.65%(44/46),特异度 100.00%(6/6),准确性86.15%(50/52), Kappa值0.84;SMI检查术后活性病灶 血供灵敏度82.61%(38/46),特异度 83.33%(5/6),准确性82.69%(43/52), Kappa值0.44;CTPI检查准确性与灵敏度 均明显高于SMI检查结果(P<0.05)。结论 两种检查方式与DSA检查结果均具有一致 性,相较于SMI,螺旋CTPI评估肝癌介入 术后活性病灶血供具有较高准确性,可为 患者预后判定提供有效指导。

Objective To compare the value of CT perfusion imaging (CTPI) versus superb microvascular imaging (SMI) in evaluating the blood supply of active lesions after interventional operation for liver cancer. Methods Forty-eight patients undergoing interventional operation for liver cancer were selected. They were examined with CTPI and SMI at 6 weeks after operation. With digital subtraction angiography (DSA) as the golden standard, the accuracy was compared between CTPI and SMI in evaluating blood supply of active lesions after interventional operation for liver cancer. Results DSA showed that of the 52 lesions, there were 46 lesions with blood supply and 6 lesions without. The sensitivity, specificity, accuracy and Kappa value of CTPI for blood supply of active lesions after operation were 95.65% (44/46), 100.00% (6/6), 86.15% (50/52) and 0.84, respectively, while those of SMRI were 82.61% (38/46), 83.33% (5/6), 82.69% (43/52) and 0.44, respectively. The accuracy and sensitivity of CTPI were significantly higher than those of SMI (P<0.05). Conclusion Results of the two examination methods are consistent with those of DSA. Compared with SMI, the accuracy of spiral CTPI is relatively higher in assessing the blood supply of active lesions after interventional operation for liver cancer, and it can provide effective guidance for evaluation of the prognosis of patients.

【关键词】 螺旋CT灌注成像;超微细血流 成像;肝癌;介入术

【中图分类号】R735.7;R445.1;R445.3

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.04.027

前言

肝癌为我国常见肿瘤,有调查显示,其死亡率在各种癌症肿 瘤中位列第二[1-2]。肝动脉化疗栓塞术(tanscatheter arterial chemoembolization,TACE)为临床治疗肝癌常用介入方法,已经在原 发性肝癌患者治疗中得到广泛应用。如何准确评估肝癌患者TACE术后 疗效,特别是术后肿瘤组织内与四周残留血供情况,直接影响后续治 疗计划。数字减影血管造影(Digital Subtraction Angiography, DSA)可以准确显示患者体内存活肿瘤血供,但具有创伤性。螺旋CT灌 注成像(CT perfusion imaging,CTPI)属于功能影像学检查方式,能 将器官组织之中血流动力学变化呈现出来。有研究表明,超声超微细 血流成像(superb microvascular imaging,SMI)具有较高分辨率,能 够敏感捕捉到较为低速血流[3]。本文以48例行肝癌介入术治疗患者作为 研究对象,分析CTPI与超声SMI对肝癌介入术后活性病灶血供的评估价 值。