目的探讨儿童神经母细胞瘤 (NB)伴骨转移的CT影像特点。方法 分析 22例NB伴骨转移患儿的临床资料，分析其 CT特点。结果 肿瘤单发者19例、多发者3 例，原发于肾上腺12例、中后纵隔6例、 椎体旁4例。22例均伴骨转移，包括脊 柱、髂骨、肋骨、胸骨及多部位转移；同 时伴肝转移3例，伴淋巴结转移4例；NB的 原发病灶瘤体较大，密度不均，多伴有钙 化和坏死，增强扫描呈轻-重度不均匀强 化，骨转移均表现为溶骨性骨破坏，部分 病灶伴钙化或垂直骨针的软组织肿块。肝 脏及淋巴结转移病灶平扫密度不均，增强 扫描呈环形或不均匀强化。结论 儿童NB 原发灶的CT表现具有一定特征性，骨转移 以溶骨性破坏为主，CT对其检出具有重要 价值。

Objective To explore the CT features of children neuroblastoma with bone metastasis. Methods The clinical data of 22 patients with NB with bone metastasis were analyzed and their CT features were analyzed. Results There were 19 cases of solitary lesion and 3 cases of multiple lesions, 6 cases located at adrenal gland and 4 cases located at vertebral body. All the 22 cases were accompanied by bone metastases, including the spine, ilium, ribs, sternum and multiple metastases. At the same time, 3 cases were accompanied with liver metastasis and 4 cases with lymph node metastasis. NB larger tumors from the primary lesion and uneven density, with calcification and necrosis, uneven enhancement scanning in light-severe reinforcement, bone metastases are characterized by dissolving osseous bone destruction, some lesions of soft tissue mass with calcification or vertical spicules. Hepatic and lymph node metastases were not evenly distributed, and the enhanced scan was annular or inhomogeneous. Conclusion The CT features of NB primary lesions in children have certain characteristics, and bone metastasis was mainly caused by osteolytic destruction, and CT has important value in detecting them.