目的通过对颅脑磁共振 (magnetic resonance imaging，MRI) 增强前后弥散加权成像 ( d i f f u s i o n weighted imaging，DWI)信号强度和 表观弥散系数(apparent diffusion coefficient，ADC)值测量来研究钆喷酸 葡胺(gadopentetate dimeglumine，GdDTPA)对弥散加权的影响。方法 自2017 年3月-2017年6月，30例行头颅磁共振平 扫和增强检查的患者纳入研究，在增强 前后均行相同参数和定位的DWI成像，并 选取对同一患者增强前后的背侧丘脑和 半卵圆中心行DWI图像信号强度和ADC值 测量,对比剂剂量为15ml。对增强前后 DWI信号强度和ADC值进行配对资料t检 验。结果 30例患者增强前后背侧丘脑和 半卵圆中心DWI图像信号强度差异有统计 学意义(P<0.01)。30例患者增强前后背 侧丘脑ADC值比较无显著性统计学差异 (P=0.055>0.05)，半卵圆中心ADC值比较 无统计学差异(P=0.084>0.05)。结论 增 强前后钆喷酸葡胺未对颅脑背侧丘脑和半 卵圆中心ADC值造成统计学差异，但DWI图 像信号强度提高。

Objective To study the effect of Gd-DTPA on before and after enhancement diffusion weighted imaging (DWI) by measuring DWI signal intensity and ADC. Methods 30 patients, DWI were included this study. DWI exam had the same parameter before and after enhancement. The ROI was dorsal thalamus and centrum ovale. The contrast medium dosage was 15ml. Two experienced radiologists evaluated the image quality of DWI in five scorescale. Student t test was used to compare the image quality. Results There was statistical difference for the intensity of DWI(P<0.01). There was no statistical difference for ADC of dorsal thalamus and centrum ovale(P>0.05). Conclusion There was no statistically significant difference in ADC between the posterior cerebral thalamus and the semi oval Center before and after enhancement .But the intensity of DWI was improved.