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18F-FDG PET/CT在结直肠癌术后患者复发及转移中的临床应用*

作者:周 胜1 潘 奇2

所属单位:1.西安医学院第二附属医院肛肠科(陕西 西安 710038) 2.西安医学院第二附属医院影像科(陕西 西安 710038)

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摘要

目的分析18F-脱氧葡萄糖(18FFDG)正电子发射计算机体层成像(PET/CT) 在结直肠癌术后患者复发及转移中的临床 应用价值。方法 选取我院行手术治疗结 直肠癌患者,均予以18F-FDG PET/CT与CT 强化检查,以活检病理学结果或者再次手 术作为“金标准”,最终诊断为结直肠癌 患者共80例,比较18F-FDG PET/CT与CT增 强检查对患者术后复发及转移诊断的准确 性、敏感度、特异度。结果 18F-FDG PET/ CT与CT增强扫描对术后复发检查特异度 比较无显著差异(χ2 =2.036,P>0.05), 18F-FDG PET/CT准确性(χ2 =5.766,P <0.05)、敏感度(χ2 =4.547,P<0.05) 明显高于CT增强扫描;18F-FDG PET/CT 对术后转移检查特异度(χ2 =6.176, P<0.05)、准确性(χ2 =13.491,P <0.05)、敏感度(χ2 =7.372,P<0.05) 明显高于CT增强扫描。结论 相较于传统 增强CT,18F-FDG PET/CT对结直肠癌术后 患者复发的诊断具有较高准确性与敏感 度,对术后转移具有较高准确性、特异度 及灵敏度,具有推广价值。

Objective To analyze the clinical value of 18F-deoxyglucose (18F-FDG) positron emission computed tomography (PET/CT) in postoperative recurrence and metastasis of colorectal cancer. Methods A total of 80 patients with colorectal cancer treated by operation in the hospital were examined with 18F-FDG PET/CT and enhanced CT. The diagnostic accuracy, sensitivity and specificity of 18F-FDG PET/CT and enhanced CT examination for postoperative recurrence and metastasis were compared with the results of biopsy and pathology or reoperation as the golden standard. Results There was no significant difference in specificity between 18F-FDG PET/CT and enhanced CT scan for postoperative recurrence (χ2 =2.036, P>0.05). The accuracy (χ2 =5.766, P<0.05) and sensitivity (χ2 =4.547, P<0.05) of 18F-FDG PET/CT were significantly higher than those of enhanced CT scan. The specificity (χ2 =6.176, P<0.05), accuracy (χ2 =13.491, P<0.05) and sensitivity (χ2 =7.372, P<0.05) of 18F-FDG PET/CT for postoperative metastasis were significantly higher than those of enhanced CT scan. Conclusion Compared with the traditional enhanced CT scan, the accuracy and sensitivity of 18F-FDG PET/CT are higher in the diagnosis of postoperative recurrence of colorectal cancer, and the accuracy, specificity and sensitivity are higher for postoperative metastasis.

【关键词】18F-脱氧葡萄糖;正电子发射计算机体层成像;结直肠癌

【中图分类号】R97;R74

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.12.039

前言

结直肠癌为消化系统高发疾病之一,在消化道肿瘤发病率中位列 第3,可对人类健康造成严重危害,其发生可能和现代人们饮食习惯 或者饮食结构变化紧密相关[1-2]。当前,手术为结直肠癌首选治疗方 法,但术后容易出现复发或转移现象。有调查表明,结直肠癌术后复 发与转移率高达7.5%~16.4%,对患者生活质量以及生存期产生严重影 响[3-4]。早期准确诊断结直肠癌术后复发与转移,可指导临床及时 修订治疗方案,有效延长生存期。CT、B超与磁共振成像(Magnetic Resonance Imaging,MRI)等均为结直肠癌术后复发、转移的有效诊断 方式,但亦各自存在一定局限性。18F-脱氧葡萄糖(18F-FDG)正电子发射 计算机体层成像(PET/CT)有机融合了解剖形态学以及功能代谢影像, 能够清晰显示解剖结构,同时呈现病灶功能的代谢情况。本文以80例 行手术治疗结直肠癌患者作为研究对象,探讨18F-FDG PET/CT在术后复 发及转移中的临床应用价值。汇报如下。