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扩散加权成像ADC值与宫颈癌组织病理学类型及分化程度的相关性分析*

作者:王亦强 贾宏波 杨东鑫

所属单位:抚顺矿务局总医院影像科(辽宁 抚顺 113000)

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摘要

目的分析扩散加权成像(DWI) ADC值与宫颈癌组织病理学类型及分化程 度的相关性。方法 选择我院经手术病理 检查确诊为宫颈癌的患者118例,术前均 进行常规磁共振成像(MRI)和扩散加权成 像(DWI)检查,获取宫颈肿瘤ADC值,分析 ADC值与宫颈癌组织病理学类型及分化程 度的相关性。结果 宫颈鳞癌患者ADC值 显著低于腺癌患者(t=4.839,P<0.05)。 不同分化程度宫颈癌患者ADC值存在差异 (P<0.05),且低分化组ADC值小于中分化 组和高分化组(P<0.05),中分化组ADC值 小于高分化组(P<0.05)。ADC值与宫颈鳞 癌分化程度呈正相关(P<0.05)。结论 宫 颈鳞癌DWI ADC值低于宫颈腺癌,ADC值与 宫颈鳞癌分化程度存在相关性,DWI ADC 值可作为临床评估宫颈癌病理类型及分化 程度的重要指标之一。

Objective To analyze the correlation between diffusion-weighted imaging (DWI) ADC values and histopathological types and differentiation degree of cervical cancer. Methods A total of 118 cases of patients diagnosed with cervical cancer by pathological examination in our hospital were selected, and they were given routine magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) before operation. The ADC values of cervical cancer were obtained, and the correlation between ADC values and histopathological types and differentiation degree of cervical cancer were analyzed. Results The ADC value of patients with cervical squamous cell carcinoma was significantly lower than that of patients with adenocarcinoma (t=4.839, P<0.05). There were significant differences in ADC values among cervical cancer patients with different differentiation degrees (P<0.05), and ADC values in poorly differentiated group were lower than those in moderately differentiated group and highly differentiated group (P<0.05), and the ADC values in moderately differentiated group were lower than those in highly differentiated group (P<0.05). The ADC value was positively correlated with the differentiation degree of cervical squamous cell carcinoma (P<0.05). Conclusion The ADC value of cervical squamous cell carcinoma is lower than that of cervical adenocarcinoma. The ADC value is correlated with the differentiation degree of cervical squamous cell carcinoma, and can be used as one of the important indexes to evaluate the pathological type and differentiation degree of cervical cancer.

【关键词】扩散加权成像;ADC值;宫颈癌;组织病理学类型

【中图分类号】R711.74

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.12.038

前言

宫颈癌是临床常见恶性肿瘤,其发病原因与病毒感染、性行为、 分娩次数等有关,发病率在女性生殖器官恶性肿瘤中排在第1位[1]。在 宫颈癌组织病理学类型中,最为常见的是鳞癌,其次为腺癌[2],病理 学类型不同,其治疗方案亦有差异。此外,肿瘤分化程度不一,对各 种治疗方法的耐受性和效果也存在区别。故了解宫颈癌组织病理学类 型及分化程度,有利于临床治疗的选择。常规磁共振成像(MRI)在肿 瘤检查中应用广泛,但难以区分不同病理类型的宫颈癌[3]。扩散加权 成像(DWI)为可反映活体组织内部结构及病理生理改变的功能MR成像 方法,可提高器官癌变检出灵敏度[4],ADC值是DWI扩散系数,与细胞 密度存在相关性[5],可在一定程度上反映肿瘤的良恶性及恶性肿瘤分 化程度。本次研究以我院118例宫颈癌患者为研究对象,术前均进行 MRI和DWI检查,分析ADC值与宫颈癌组织病理学类型及分化程度的相关 性。具体报道如下。