目的本研究旨在通过对核磁共 振DWI的研究，分析ADC值在评估代偿期乙 肝肝硬化相关肾功能改变的应用价值。 方法 2015年7月至2017年1月，在我院就 诊的46例乙肝代偿期肝硬化患者纳入研 究组，搜集40例健康正常志愿者作为对照 组。入组均接受1.5T磁共振扫描，扩张加 权成像b值选择600s/mm2 ，后处理工作站 测量肾脏ADC值。采用配对样本t检验比 较两组左右肾脏ADC值的差异。两个独立 样本t检验比较两组之间肾脏ADC值的差 异。采用ROC曲线分析指标的诊断效能。 结果 研究组内、对照组内双侧肾脏平均 ADC 值差异无统计学意义(P>0.05)。研究 组和对照组双肾平均ADC值差异有统计学 意义(P<0.01)。ROC 曲线分析显示，ADC 值1.93×10-3mm2 /s作为临界值，敏感度为 80.4%，特异度为76.9%，ROC曲线下的面 积为0.72。结论 作为无创性功能成像技 术，ADC值可以作为评估和随访代偿期乙 肝肝硬化相关肾功能的有效方法。

Objective The aim of study was to investigate Diffusion-weighted imaging (DWI), and to analyze the value of ADC value in the evaluation of renal function after chronic hepatitis B compensated cirrhosis. Methods From July 2015 to January 2017, 46 patients with chronic hepatitis B compensated cirrhosis in the hospital were enrolled in this study. And 40 healthy outpatients were enrolled as control group. In both experimental and control group, 1.5T magnetic resonance imaging was performed, and the expansionweighted imaging b value was chosen to be 600s/mm2 . The post-processing work station measured the each group renal of ADC value. The paired-samples t test was conducted to analyze the difference of ADC value between the right and left renal in each group. The difference of ADC value between experimental and control group was analyzed by independent t test. The ROC curve was used to analyze the distinguishing value of ADC value among the groups. Results No statistical differences were found in ADC value between the right and left renal in each group(P>0.05). There was a significant difference of ADC value between experimental and control group(P<0.01). ROC analysis showed that the area under the ROC curve (AUC) for ADC value was 0.72 and that the optimal cut off value of ADC for differentiating experimental and control group was 1.93×10- 3 mm2 /s (sensitivity, 80.4%, specificity, 76.9%). Conclusion The noninvasive and noncontrast agent needed characteristic might make ADC value an effective method for detecting and monitoring kidney function in patients with chronic hepatitis B compensated cirrhosis.