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侵袭性垂体瘤术前MRI信号特征及其诊断价值*

作者:熊鹏举 邓 磊 钱锁开

所属单位:中国人民解放军第九四医院神经外科(江西 南昌 330002)

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摘要

目的探究侵袭性垂体瘤术前磁 共振成像(MRI)信号特征及其诊断价值。 方法 回顾性分析2015年2月至2017年12月 我院收治的55例侵袭性垂体瘤患者的临床 资料,所有患者均行MRI扫描,测量肿瘤 的最大直径,记录肿瘤的形态、部位、 信号强度特点,向周围组织浸润程度及方 向。结果 侵袭性垂体瘤MRI表现为T1WI扫 描呈等、稍低信号,T2WI呈等或稍高信 号;55例患者垂体瘤均对周围组织结构有 不同程度的侵犯,表现为海绵窦不同程度 侵犯、束腰征、鞍底塌陷、骨质吸收变 薄等特征;MRI诊断鞍上及鞍内侵犯符合 率为100.00%,诊断海绵窦侵犯符合率为 90.00%。结论 MRI及动态增强扫描可较好 的显示侵袭性垂体瘤大小、位置、生长方 向及其与周围组织的关系,对临床手术术 式选择及预后判断具有指导作用。

Objective To investigate the preoperative magnetic resonance imaging (MRI) signal features of invasive pituitary tumors and their diagnostic value. Methods The clinical data of 55 patients with invasive pituitary tumors who were admitted to the hospital during the period from February 2015 to December 2017 were analyzed retrospectively. All patients underwent MRI scan and the maximum diameter of the tumor was measured. The shape, location, signal intensity, infiltration degree of surrounding tissues and the direction of tumors were recorded. Results MRI findings of invasive pituitary tumors showed slightly lower and equal signals on T1WI scan, and equal or slightly higher signals on T2WI. There were different degrees of invasion of surrounding tissue structure by pituitary tumors in 55 cases, showing different degrees of invasion of cavernous sinus, hourglass signs, collapse of sellar floor and thinning of bone resorption, etc. The coincidence rates of MRI in the diagnosis of invasion above and in the saddle was 100.00%, and in the diagnosis of cavernous sinus invasion was 90.00%. Conclusion MRI and dynamic contrast-enhanced scan can better display the size, location, growth direction of invasive pituitary adenoma and its relationship with surrounding tissues, and can guide the choice of surgical methods and prognosis.

【关键词】垂体瘤;侵袭性;磁共振成像;诊断价值

【中图分类号】R73;R74

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.12.002

前言

垂体瘤是临床常见颅内肿瘤,约占原发性颅内肿瘤的10~15%, 90%垂体瘤为良性腺瘤,少数为增生,极少数为癌[1]。根据其生物学行 为可将垂体瘤分为侵袭性肿瘤及非侵袭性肿瘤,其中侵袭性垂体瘤生 物学行为与恶性肿瘤类似,此类肿瘤可侵犯周围组织结构,压迫视神 经可造成视力下降,压迫第三脑室可产生脑积水症状,威胁患者身体 健康及生活质量[2-3]。目前临床治疗垂体腺瘤主要采用外科手术,其 中经鼻蝶入路是常见手术方式,对于部分无广泛侵袭的肿瘤可轻松切 除,但对于侵袭性垂体瘤,因侵犯临近组织,解剖结构复杂,手术难 以彻底清除,术后极易复发,因此术前了解肿瘤生长方式及其与周围 组织的关系对于手术效果及预后具有重要的临床意义[4]。随着影像学 技术的发展,磁共振成像(MRI)被广泛用于颅脑肿瘤的诊断中,取得良 好的效果[5]。本研究回顾性分析了经手术及病理证实的55例侵袭性垂 体瘤患者的临床资料,分析术前垂体瘤的MRI影像学特征,探讨MRI对 侵袭性垂体瘤的诊断价值。现报道如下。