目的探讨乳腺癌的MRI表现与 ER、PR、HER-2水平之间的关系。方法 选 取97例手术病理证实为浸润性导管癌的患 者，术前均行乳腺常规MRI扫描。分析乳 腺癌的MR毛刺、分叶征与ER、PR、HER-2 表达的相关性。采用卡方检验，P＜0.05 认为差异有统计学意义。结果 在97例浸 润性导管癌患者中，有毛刺组的ER、PR、 HER-2阳性表达率高于无毛刺组的ER、 PR、HER-2的阳性率，经统计学分析差异 有统计学差异(P＜0.05)；有分叶组的PR 阳性表达率低于无分叶组的PR阳性表达 率。有分叶组的ER、HER-2阳性表达率高 于无毛刺组的ER、HER-2表达率，其中， 分叶征与HER-2表达经统计学分析有显著 性差异(P＜0.05)。结论 ER、PE、HER-2 的表达与浸润性导管癌的毛刺征有关， HER-2的表达与分叶征相关；乳腺癌的MRI 表现有一定的特征，其与乳腺癌各生物学 指标密切相关，在一定程度上可为临床治 疗方法的选择提供参考。

Objective To investigate the MRI feature of invasive ductal carcinoma (IDC) in correlation with the expressions of ER, PR and HER-2. Methods A total of 97 patients with histologically confirmed IDC were enrolled in this study. Conventional MRI was performed on all patients before surgery. The relationships among MRI features(spicule sign and lobulation sign) and expressions of ER, PR and HER-2 were analyzed. Statistical analysis was performed using chi-square test with statistical significance defined as P＜0.05. Results The tumors with speculated margins had higher expression levels of ER, PR and HER-2 than tumor with spiculation(P＜0.05). There were also relative lower expression levels of PR in tumors with lobulation than tumors without lobulation(P＜0.05) whereas tumor with lobulated margins had higher expression levels of ER and HER-2 than tumor without lobulation(P＜0.05). Conclusion The expression of ER, PE and HER-2 is related to the burr sign of infiltrating ductal carcinoma, and the expression of HER-2 is related to lobulated sign. It has important clinical significance for the comprehensive evaluation of the degree of malignancy of breast cancer．