目的 总结分析婴幼儿脑皮质 层状坏死的磁共振图像特点，提高对此 征象的认识。方法 回顾性分析2012年5 月-2016年1月经MR检查发现脑皮质层状坏 死的29例婴幼儿患者MR图像，总结CLN的 MR影像特点及后遗改变。结果 29例患儿 中，化脓性脑膜脑炎8例，急性脑梗7例， 病毒性脑炎5例，脑外伤5例，缺血缺氧 性脑病并低血糖脑病4例。MR于发病之日 起平均19.3天发现CLN，呈脑回样T1WI及 FLAIR高信号。19例患儿急性期DWI示病变 部位皮层高信号，T1WI及FLAIR序列无高 信号，复查MR示原DWI高信号部位出现脑 回样T1WI高信号，且范围与DWI一致，此 时DWI高信号范围较T1WI小。19例患儿随 访1-28月，病变多数持续存在(16/19)， 且CLN部位出现脑软化和(或)脑萎缩。结 论 婴幼儿CLN多见于化脓性脑膜脑炎、病 毒性脑炎、急性脑梗、脑外伤、缺血缺氧 性脑病及低血糖脑病患儿，MR图像有特征 性改变，DWI可早期预测CLN部位及范围， CLN可持续存在2年左右，并可导致病变部 位遗留脑软化和(或)脑萎缩。

Objective To investigate the MR imaging features of infant cerebral cortical laminar necrosis. Methods We retrospectively analyzed the MR images of 29 infant CLN patients, who were examined in our MR department from May 2012 to January 2016. We studied the MR imaging characteristics and after-effect signs. Results 8 cases were diagnosed suppurative meningitis, 7 cases were diagnosed ACI, 5 cases were diagnosed viral encephalitis, 5 cases were diagnosed cerebral trauma, 4 cases were diagnosed HIE and hypoglycemic encephalopathy. CLN could be found in 19.3 days after the illnesses attack. CLN appeared gyriform high signal in T1WI and FLAIR. At the acute phase,the CLN range in T1WI was same with in DWI. In DWI, The cortex lesions appeared diffusionlimited at the acute phase,there were no high signals in the T1WI or FLAIR. At this moment, the range of high signals in DWI less than in T1WI. 19 cases were followedup 1-28 months, the CLN were existed and accompanied with encephalomalacia and/or encephalatrophy. Conclusion The CLN of infant was mostly happened to suppurative meningitis, ACI, viral encephalitis, cerebral trauma, HIE and hypoglycemic encephalopathy. Typical imaging features of CLN is gyriform high signal in T1WI and FLAIR. DWI could early forecast the position and the range of CLN. The CLN could existed in almost 2 years. The prognosis is not good.