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DWI联合CT增强扫描在评估TACE治疗肝 癌患者的临床价值

作者:曾 春

所属单位:湖北省松滋市人民医院放射科(湖北 松滋 434200)

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摘要

目的 探讨扩散加权成像(DWI)联 合CT增强扫描对动脉化疗栓塞术(TACE) 治疗肝癌患者疗效评估的临床价值。方 法 以我院2012年1月-2015年1月收治的40 例肝癌患者为研究对象,均行TACE治疗, 术后4-6周行DWI检查及CT增强扫描,以术 后再次数字血管减影造影(DSA)肿瘤染色 结果为标准,分析DWI、CT增强扫描及两 者联合对患者术后肿瘤残留或复发评估敏 感度、特异度及准确度。结果 TACE术后 MRI或CT复查发现病灶95个,DSA证实病灶 阳性77个,阴性18个。以DSA结果为金标 准,DWI联合CT增强扫描敏感度100.0%, 特异度94.4%,准确度98.9%,CT增强扫描 敏感度、特异度、准确度分别为84.4%、 88.9%、85.3%。结论 DWI联合CT增强扫描 对TACE术后病灶残留或复发检出率比DWI 或CT增强扫描高,可作为肝癌患者TACE治 疗效果评估的主要手段。

Objective To investigate the clinical value of diffusion weighted imaging (DWI) combined with CT enhanced scan in the evaluation of the curative effect of transcatheter arterial chemoembolization (TACE) in the treatment of patients with liver cancer. Methods 40 patients with liver cancer treated in our hospital from January 2012 to January2015 were taken as the research objects and were treated with TACE. In postoperative 4 to 6 weeks, DWI and CT enhanced scan were performed. The results of postoperative digital subtraction angiography (DSA) tumor staining again were taken as the golden standard to analyze the sensitivity, specificity and accuracy of DWI and CT enhanced scan and the combination of the two in the evaluation of tumor residual or recurrence. Results After TACE, 95 lesions were found by MRI or CT reexamination, 77 positive lesions were confirmed by DSA and 18 lesions were negative. Taking the results of DSA were taken as the golden standard, the sensitivity of DWI combined with CT enhanced scan was 100.0%, specificity 94.4% and accuracy 98.9%. The sensitivity, specificity and accuracy of CT enhanced scan were 84.4%, 88.9% and 85.3%, respectively. Conclusion The detection rate of DWI combined with CT enhanced scan in tumor residue or recurrence after TACE was higher than that of DWI or CT enhanced scan, which can be used as a major method in the evaluation of the curative effect of TACE in the treatment of patients with liver cancer

【关键词】扩散加权成像;CT增强扫描; 动脉化疗栓塞术;肝癌

【中图分类号】R445.3;R735.7

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2016.04.025

前言

据统计,我国肝癌发病率在全球病患中占1/2以上,通常发病急 且进展快,具有肿瘤多发、恶性率高特点[1],进而大部分患者失去手 术切除机会(手术切除率约20%)。经导管动脉化疗栓塞术(TACE)为微 创非手术治疗,安全性高且见效快,已然成为非手术患者治疗重要手 段[2]。临床发现TACE术后肿瘤残留及复发情况正确判断,对其疗效评 估及后续治疗指导具有十分重要意义。目前临床关于扩散加权成像 (DWI)、CT扫描对肝癌患者TACE术后疗效或随访研究较多,但关于DWI 联合CT增强扫描对TACE术后疗效评估研究基本没有。基于此,本研究 以TACE术后再次数字血管减影造影(DSA)结果为标准,分析DWI联合CT 增强扫描对肝癌患者行TACE治疗效果评估的临床价值,报告如下。